This guide was made with Debian based distros in mind but in theory should work with anything but that. This guide expects you to have an intermediate grasp of Linux: know how to use and install programs with the terminal, able to understand online installation guides.
How to Set Up the Bare Minimum to Mod on Linux
Step 1: WINE & protontricks
Step 2: Install winetricks using the terminal: https://github.com/Winetricks/winetricks#installing
Step 3: Install protontricks using the terminal: https://simpler-website.pages.dev/html/2021/1/protontricks/
Step 2: Mod Organizer 2 for Linux
The MO2 directory path should be something like this: …/SteamLibrary/steamapps/compatdata/377160/pfx/drive_c/users/steamuser/AppData/Local/ModOrganizer
Install F4SE how you normally would on Windows, launch the game through F4SE launcher in MO2. Once you’re certain F4SE or any mod you’ve installed is working, we can now move on to installing VC Redistributables 2015-2022
Step 3: VC Redistributables 2015-2022
protontricks 377160 win7 protontricks 377160 shell
At this point, if the terminal changed directory to compatdata folder then you’re in the clear. Proceed with these commands:
wine <Path to x86 installer here>/VC_redist.x86.exe wine <Path to x86 installer here>/VC_redist.x64.exe
wine /home/conundroy/Downloads/VC_redist.x86.exe wine /home/conundroy/Downloads//VC_redist.x64.exe
For each installation prompt, proceed how you normally would on Windows.
Once installation is complete, the best way to test if it’s working is to install Buffout 4, run the game via MO2 and exit then check if a log was created, the log file file can be found in …/SteamLibrary/steamapps/compatdata/377160/pfx/drive_c/users/steamuser/My Documents/My Games/Fallout4/F4SE/Buffout4.log
If so, then congratulations, installation was successful, and you can now mod Fallout 4 on Linux to your heart’s content
Thanks to Conundroy for his great guide, all credit to his effort. you can also read the original guide from Steam Community. enjoy the game.